Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301122271?client_source=feed&format=rss
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Wednesday, April 24, 2013
Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
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Public release date: 23-Apr-2013[ | E-mail |
Share ] Contact: Kim Polacek
kim.polacek@moffitt.org
813-504-9706
H. Lee Moffitt Cancer Center & Research Institute
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA.
According to the researchers, p53 is highly inducible by radiation. Activation of p53 stabilizes chromosomes by promoting the repair of heterochromatin DNA, which controls the expression of nearby genes and ensures accurate distribution of chromosomes during cell division.
Their findings, which published online Feb. 4 in Oncogene, are significant because they shed light on the consequence of p53 deficiency that frequently occurs in tumors and further explain the function of p53 in the development of cancer.
Crucial to multicellular organisms, p53 is a tumor suppressor that regulates the cell cycle and helps prevent cancer by maintaining genetic stability and inhibiting gene mutation. But after irradiation, p53 deficiency results in abnormal levels of SUV39H1 and JMJD2b, enzymes that play a vital role in the structure of chromosomes, especially in DNA damage control and repair.
"Different tumor types have variable responses to ionizing radiation," explained study lead author Jiandong Chen, Ph.D., senior member of the Cancer Biology and Molecular Medicine Program at Moffitt. "Radiation therapy is more effective if tumors are defective in repairing damaged DNA. The p53 pathway is compromised to different degrees in all tumors, which may explain the fact that radiation often kills tumor cells more than normal cells."
In this study, the researchers worked with multiple cancer cell lines.
"We found that p53 activates JMJD2b and represses SUV39H1," Chen said. "Depletion of JMJD2b, or sustained expression of SUV39H1, delays the repair of heterochromatin DNA after ionizing radiation," explained Chen. "The DNA repair function of p53 may be particularly important in higher organisms because of the increased complexity of their genomes."
Although they note that there is no general consensus on the relationship between p53 mutation status and treatment response, in certain narrow settings such as breast cancer, p53 mutation is associated with favorable response to chemotherapy.
"We can conclude that the chromatin modifiers SUV39H1 and JMJD2b are important mediators of p53 function in maintaining the stability of highly repetitive DNA sequences, and developing new drugs that target these enzymes may benefit cancer therapy," the researchers wrote.
###
This work is supported by grants from the National Institutes of Health (CA141244, CA109636).
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.
Media release by Florida Science Communications
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 23-Apr-2013[ | E-mail |
Share ] Contact: Kim Polacek
kim.polacek@moffitt.org
813-504-9706
H. Lee Moffitt Cancer Center & Research Institute
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA.
According to the researchers, p53 is highly inducible by radiation. Activation of p53 stabilizes chromosomes by promoting the repair of heterochromatin DNA, which controls the expression of nearby genes and ensures accurate distribution of chromosomes during cell division.
Their findings, which published online Feb. 4 in Oncogene, are significant because they shed light on the consequence of p53 deficiency that frequently occurs in tumors and further explain the function of p53 in the development of cancer.
Crucial to multicellular organisms, p53 is a tumor suppressor that regulates the cell cycle and helps prevent cancer by maintaining genetic stability and inhibiting gene mutation. But after irradiation, p53 deficiency results in abnormal levels of SUV39H1 and JMJD2b, enzymes that play a vital role in the structure of chromosomes, especially in DNA damage control and repair.
"Different tumor types have variable responses to ionizing radiation," explained study lead author Jiandong Chen, Ph.D., senior member of the Cancer Biology and Molecular Medicine Program at Moffitt. "Radiation therapy is more effective if tumors are defective in repairing damaged DNA. The p53 pathway is compromised to different degrees in all tumors, which may explain the fact that radiation often kills tumor cells more than normal cells."
In this study, the researchers worked with multiple cancer cell lines.
"We found that p53 activates JMJD2b and represses SUV39H1," Chen said. "Depletion of JMJD2b, or sustained expression of SUV39H1, delays the repair of heterochromatin DNA after ionizing radiation," explained Chen. "The DNA repair function of p53 may be particularly important in higher organisms because of the increased complexity of their genomes."
Although they note that there is no general consensus on the relationship between p53 mutation status and treatment response, in certain narrow settings such as breast cancer, p53 mutation is associated with favorable response to chemotherapy.
"We can conclude that the chromatin modifiers SUV39H1 and JMJD2b are important mediators of p53 function in maintaining the stability of highly repetitive DNA sequences, and developing new drugs that target these enzymes may benefit cancer therapy," the researchers wrote.
###
This work is supported by grants from the National Institutes of Health (CA141244, CA109636).
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.
Media release by Florida Science Communications
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/hlmc-dip042213.php
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Tuesday, April 23, 2013
AT&T Galaxy S4 arriving in stores ahead of schedule on April 27th
By Karolos Grohmann DORTMUND, Germany, April 23 (Reuters) - Manchester United's Premier League title win came as no surprise to Real Madrid coach Jose Mourinho, who praised coach Alex Ferguson on Tuesday and said winning was his life. Mourinho, who challenged United's domestic dominance while at Chelsea between 2004-2007, was speaking Real's their Champions League semi-final against Borussia Dortmund. Real eliminated United in the last 16. "What he did is what he has been doing all his life, winning," Mourinho told reporters. "Sometimes not consecutively because it is impossible to do it. ...
Source: http://news.yahoo.com/t-galaxy-s4-arriving-stores-ahead-schedule-april-144007571.html
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U.N. nuclear agency in talks about talks with Iran
VIENNA/DUBAI (Reuters) - The U.N. nuclear agency is talking with Iran to set a date for discussions on resuming an investigation there, it said on Monday, as Washington stressed the importance of diplomacy in ending a standoff over Tehran's nuclear program.
The International Atomic Energy Agency (IAEA), which wants to restart a long-stalled inquiry into suspected atomic bomb research, issued a brief statement after Iranian media reported that talks were set for May 21.
The IAEA has been trying for more than a year to coax Iran into granting IAEA officials the access they want. Western diplomats accuse Iran of stonewalling and some say the IAEA may soon need to get tougher with the Islamic Republic.
Asked about the Iranian media reports, IAEA spokeswoman Gill Tudor said in an email: "I can confirm we are discussing possible dates of a meeting with Iran."
Iran's Mehr and ISNA news agencies initially reported that the meeting would be held on May 21, but ISNA later quoted an unnamed official as saying this was only a "preliminary agreement" and that the date could be moved by one or two days.
The IAEA-Iran talks are separate from, but have an important bearing on, diplomatic negotiations between Tehran and six world powers aimed at a broad settlement to the decade-old dispute and reduce the risk of a new Middle East war.
Western powers suspect Iran is trying to develop the capability to produce nuclear weapons under the guise of a declared civilian atomic energy program. Iran denies this, saying it seeks only electricity and medical applications from uranium enrichment.
But its refusal to curb sensitive nuclear activity with both civilian and military applications and its lack of openness with IAEA inspectors have drawn U.N. and Western sanctions.
Israel, widely believed to be the only nuclear-armed power in the Middle East, has long hinted at possible air strikes to deny Iran any means to make an atomic bomb.
But the Jewish state suggested on Monday it would be patient before taking any military action against Iran's nuclear sites, saying during a visit by U.S. Defense Secretary Chuck Hagel there was still time for other options.
Thomas Countryman, U.S. assistant secretary for international security and nonproliferation, told reporters in Geneva that the prospect of a nuclear-armed Iran was "a threat to the entire region and an impetus for greater proliferation," but he stressed the value of diplomacy.
"The fact is that it is concerted international diplomatic action with the full range of diplomatic tools, including strong economic sanctions, that have brought Iran to the negotiating table," Countryman told a news conference.
"They have not yet succeeded in getting Iran to negotiate seriously on the world's concerns, but they have brought us to the table."
Some analysts and diplomats say Iran's leadership may be unwilling or unable to make important decisions in nuclear negotiations before its presidential election in June.
If the Iran-IAEA meeting were to take place, it would be the 10th between the two sides since early 2012, so far without a deal that would enable the U.N. watchdog to gain access to sites, documents and officials for the inquiry.
Officials at Iran's IAEA mission were not immediately available for comment. The last round of IAEA-Iran negotiations, in February, yielded no breakthrough.
(Reporting by Yeganeh Torbati in Dubai, Fredrik Dahl in Vienna, Stephanie Nebehay in Geneva and Zahra Hosseinian in Zurich; Editing by Robin Pomeroy)
Source: http://news.yahoo.com/iran-u-n-nuclear-watchdog-hold-round-talks-082314738.html
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Monday, April 22, 2013
Terrible Advice From a Great Scientist
Increasingly it does (minus the artsy chick, some fantasies never die). Very few current articles in biology have been written by one or two people. Even those articles have a long list of people that the researchers relied on for technical and intellectual support. It's not Charles Darwin walking down the road any more.
While there may be great insights developed by single 'intuitive' biologists, the intellectual foundations of those insights are going to come from thousands of disparate people. DNA chemistry and sequencing is an example here - how many biologists understand the chemistry of the analyzers? How many chemists understand the software?
I don't think H.O. is really correct though. At the complexity level that biologists are working at 'intuitive' thinking isn't going to help much. Working the numbers will.
I'd rather train a mathematician to be a biologist than the other way around.
Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/9M2q6uv0OX0/story01.htm
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Affidavit: Maine hermit carried bacon, syrup, $395
AUGUSTA, Maine (AP) ? A state police affidavit says a Maine man who lived in the woods as a hermit for nearly three decades was carrying bacon, marshmallows and $395 in cash when he was arrested on burglary charges.
An affidavit obtained by the Kennebec Journal (http://bit.ly/13oW4cH ) lists the items 47-year-old Christopher Knight possessed when he was arrested this month on charges he stole food from a camp for children with special needs.
The items also include keys, pliers, electrical tape, a watch, a baseball hat, coffee, hamburger patties, chicken nuggets, cheese, corn syrup and potato chips.
Since his arrest, Knight has attracted a telephoned marriage proposal and a stranger's offer to bail him out. Knight rejected the bail offer and remains jailed.
Police say he may have been responsible for 1,000 burglaries overall.
___
Information from: Kennebec Journal, http://www.kjonline.com/
Source: http://news.yahoo.com/affidavit-maine-hermit-carried-bacon-syrup-395-163646408.html
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Boston Globe Endorses Ed Markey Over Stephen Lynch In Massachusetts Senate Race
Robert Byrd (D-W.V.)
<strong>Dates of service:</strong> Jan. 3, 1959 to June 28, 2010 <strong>Years of service:</strong> 51 years, 5 months, 26 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Robert Byrd, D-W.V., appears at a Senate hearing on May 9, 2007 in Washington. He died on June 28, 2010 at the age of 92. (KAREN BLEIER/AFP/Getty Images)
Daniel Inouye (D-Hawaii)
<strong>Dates of service:</strong> Jan. 3, 1963 to Dec. 17, 2012 <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Senate Appropriations Defense Subcommittee Chairman Daniel Inouye (D-HI) speaks at a May 18, 2011 hearing in Washington. (Chip Somodevilla/Getty Images)
Strom Thurmond (R-S.C.)
<strong>Dates of service:</strong> Dec. 14, 1954 to April 4, 1956 and Nov 7, 1956 to Jan 3, 2003 <strong>Years of service:</strong> 47 years, 5 months, 8 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Senator Strom Thurmond, R-S.C., pictured on May 22, 1997. He died on June 26, 2003 at the age of 100. (STEPHEN JAFFE/AFP/Getty Images)
Edward Kennedy (D-Mass.)
<strong>Dates of service:</strong> Nov. 7, 1962 to Aug. 25, 2009 <strong>Years of service:</strong> 46 years, 9 months, 19 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Edward Kennedy (D-Mass.) speaks during a Jan. 21, 2007 taping of NBC's "Meet the Press." He died on Aug. 25, 2009 at the age of 77. (Photo by Alex Wong/Getty Images)
Carl Hayden (D-Ariz.)
<strong>Dates of service:</strong> March 4, 1927 to Jan. 3, 1969 <strong>Years of service:</strong> 41 years, 9 months, 30 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> President Lyndon Johnson presents a pen to Sen. Carl Hayden, D-Ariz., on September 30, 1968 in Washington. Hayden died on Jan. 25, 1972 at the age of 94. (AP Photo)
John Stennis (D-Miss.)
<strong>Dates of service:</strong> Nov. 5, 1947 to Jan. 2, 1989 <strong>Years of service:</strong> 41 years, 1 month, 29 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> John Stennis, chairman of the Senate Armed Services Committee, speaks on the July 6, 1969 edition of ABC's "Issues and Answers." Stennis died on April 23, 1995 at the age of 93. (AP Photo)
Ted Stevens (R-Alaska)
<strong>Dates of service:</strong> Dec. 24, 1968 to Jan. 2, 2009 <strong>Years of service:</strong> 40 years, 10 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> In this Tuesday, April 7, 2009 file photo, former Sen. Ted Stevens arrives at federal court in Washington. Stevens died in a plane crash on Monday, Aug. 9, 2010 at the age of 86. (AP Photo/Gerald Herbert, file)
Ernest Hollings (D-S.C.)
<strong>Dates of service:</strong> Nov. 9, 1966 to Jan. 2, 2005 <strong>Years of service:</strong> 38 years, 1 month, 25 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Ernest Hollings, D-S.C., appears at a Town Hall on Thursday, Oct. 7, 1983. He ran for the 1984 Democratic presidential nomination, but lost out to Vice President Walter Mondale. (AP Photo/Ron Frehm)
Richard Russell (D-Ga.)
<strong>Dates of service:</strong> Jan. 12, 1933 to Jan. 21, 1971 <strong>Years of service:</strong> 38 years, 19 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Richard Russell (D-Ga.), shown from his Senate office desk in Washington on July 14, 1942. Russell died on Jan. 21, 1971 at age 73. (AP Photo/Eugene Abbott)
Russell Long (D-La.)
<strong>Dates of service:</strong> Dec. 31, 1948 to Jan. 2, 1987 <strong>Years of service:</strong> 38 years, 3 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Russell Long, shown at his desk in Baton Rouge, La., on Feb. 21, 1948. Long died on May 9, 2003 at age 84. (AP Photo)
Patrick Leahy (D-Vt.)
<strong>Dates of service:</strong> Jan. 3, 1975 to present <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Patrick Leahy, D-Vt., stands in front of the U.S. Capitol building on Monday, Nov. 26, 2007. (AP Photo/Charles Dharapak)
Francis Warren (R-Wyo.)
<strong>Dates of service:</strong> Nov. 18, 1890 to March 3, 1893 and March 4, 1895 to Nov. 24, 1929 <strong>Years of service:</strong> 37 years, 4 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> (Photo by Alex Wong/Getty Images)
James Eastland (D-Miss.)
<strong>Dates of service:</strong> June 30, 1941 to Sept. 28, 1941 and Jan. 3, 1943 to Dec. 27, 1978 <strong>Years of service:</strong> 36 years, 2 months, 24 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. James O. Eastland of Mississippi, is shown in Washington on March 25, 1971. Eastland died on Feb. 19, 1986 at age 81. (AP Photo / Charles Tasnadi)
Warren Magnuson (D-Wash.)
<strong>Dates of service:</strong> Dec. 14, 1944 to Jan. 2, 1981 <strong>Years of service:</strong> 36 years, 20 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Then-Rep. Warren Magnuson (D-Wash.) smiles in his Washington office on Oct. 19, 1943. Magnuson died on May 20, 1989 at the age of 84. (AP Photo)
Joe Biden (D-Del.)
<strong>Dates of service:</strong> Jan. 3, 1973 to Jan. 15, 2009 <strong>Years of service:</strong> 36 years, 13 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Democratic vice presidential candidate and U.S. Senator Joe Biden (D-Del.) speaks at a rally in support of then-Democratic presidential nomineee U.S. Sen. Barack Obama (D-IL) on October 12, 2008 in Scranton, Pa. (Photo by Jeff Fusco/Getty Images)
Pete Domenici (R-N.M.)
<strong>Dates of service:</strong> Jan. 3, 1973 to Jan. 2, 2009 <strong>Years of service:</strong> 36 years <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> U.S. Republican Sen. Pete Domenici (R-N.M.) listens during the announcement of the America Competes Act on March 5, 2007 in Washington. (MANDEL NGAN/AFP/Getty Images)
Claiborne Pell (D-R.I.)
<strong>Dates of service:</strong> Jan. 3, 1961 to Jan. 2, 1997 <strong>Years of service:</strong> 36 years <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> U.S. Sen. Claiborne Pell, D-R.I., announces on Sept. 5, 1995 that he would not seek a seventh term in office. Pell died on Jan. 1, 2009 at age 90. (AP Photo/Charles Krupa) (AP Photo/Charles Krupa, File)
Kenneth McKellar (D-Tenn.)
<strong>Dates of service:</strong> March 4, 1917 to Jan. 2, 1953 <strong>Years of service:</strong> 35 years, 10 months <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Kenneth McKellar (D-Tenn) left, and James M. Landis, OCD director meet on Feb. 27, 1942. McKellar died on Oct. 25, 1957 at age 88. (AP Photo)
Milton Young (R-N.D.)
<strong>Dates of service:</strong> March 12, 1945 to Jan. 2, 1981 <strong>Years of service:</strong> 35 years, 9 months, 22 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Secretary of State Henry Kissinger, left, chats to Senator John L. McClellan (D-Ark.), center, and Senator Milton Young (R-N.D.), at the White House in Washington, March 24, 1975. Young died on May 31, 1983 at the age of 85. (AP Photo)
Ellison Smith (D-S.C.)
<strong>Dates of service:</strong> March 4, 1909 to Nov. 17, 1944 <strong>Years of service:</strong> 35 years, 8 months, 13 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Ellison Smith (left) meets with Secretary of Agriculture, Henry Wallace (right) on Jan. 18, 1934 in Washington. Smith died on Nov. 17, 1944 at age 80. (AP Photo)
Allen Ellender (D-La.)
<strong>Dates of service:</strong> Jan. 3, 1937 to July 27, 1972 <strong>Years of service:</strong> 35 years, 6 months, 24 days <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Allen Ellender, D-La., bids goodbye to Mrs. Ladybird Johnson after a gumbo luncheon at the Capitol on August 21, 1964. Ellender died on July 27, 1972 at age 81. (AP Photo)
William Boyd Allison (R-Iowa)
<strong>Dates of service:</strong> March 4, 1873 to Aug. 4, 1908 <strong>Years of service:</strong> 35 years, 5 months <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a>
Orrin Hatch (R-Utah)
<strong>Dates of service:</strong> Jan 3. 1977 to present <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> U.S. Sen. Orrin Hatch (R-Utah) heads to a weekly policy meeting at the Capitol on March 20, 2012 in Washington. (Photo by T.J. Kirkpatrick/Getty Images)
Richard Lugar (R-Ind.)
<strong>Dates of service:</strong> Jan 3. 1977 to present <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> Sen. Richard Lugar attends a courtesy call to the Malacanang Palace in Manila on October 29, 2012. (NOEL CELIS/AFP/Getty Images)
John McClellan (D-Ark.)
<strong>Dates of service:</strong> Jan. 3, 1943 to Nov. 28, 1977 <strong>Years of service:</strong> 34 years, 11 months <strong>Source:</strong> <a href="http://www.senate.gov/senators/Biographical/longest_serving.htm">United States Senate</a> A portrait of John McClellan, who served in the U.S. House of Representatives from 1935-38 and served in the Senate from 1943 until his death in 1977. (Photo by Hulton Archive/Getty Images)
Source: http://www.huffingtonpost.com/2013/04/21/boston-globe-ed-markey_n_3128284.html
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