Saturday, June 30, 2012

Wisconsin Agency's 'Deserve to Die' Campaign Puts Lung Cancer in ...

A funny thing happens when you plaster U.S. cities with posters saying certain types of people "deserve to die." Namely, those people get a bit upset. Wisconsin agency Laughlin Constable and the Lung Cancer Alliance learned that this week when they launched teaser ads with messages like "Hipsters Deserve to Die" and "Cat Lovers Deserve to Die." The posters sparked news coverage in cities like Chicago, where some residents reportedly tore down some of the ads in anger. The lung cancer advocacy campaign, actually called "No One Deserves to Die," was supposed to be revealed at midnight today, but the full site seems to have gone live Wednesday after reporters began covering the public's reaction.?"We knew that one would be polarizing," Laughlin Constable strategy vp Denise Kohnke told a Milwaukee TV station. One problem with the campaign is that the message is a bit difficult to grasp in short bites of copy. It's better explained on the website?(be sure to scroll all the way down), which describes how lung cancer victims are unfairly stigmatized as having brought the disease on themselves. The result is that, despite being the "deadliest cancer," lung cancer is the least funded in terms of research. "Lung cancer doesn't discriminate, and neither should you," the site says. "Help put an end to the stigma and the disease." That's a bold and socially complex message, one that's tough to decipher from any ad, much less one that says ?[a modern social archetype] deserves to die." But what do you think? Will it work?

Source: http://www.adweek.com/adfreak/deserve-die-campaign-puts-lung-cancer-spotlight-141508

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London Welsh on the up after appeal

The Championship winners were originally denied the right to go up after being told they had failed to meet the minimum standards required of a Premiership club.

London Welsh's appeal was heard on Thursday by an independent panel, who spent all of Friday deliberating over the evidence before finding in favour of the Richmond-based club. The verdict condemns Newcastle to relegation after they finished bottom of the Premiership.

London Welsh were initially told they had failed the minimum standards audit on a number of factors but primarily because they did not meet the requirement for primacy of tenure.

In effect, that meant London Welsh were not allowed to share the Kassam Stadium with Oxford United even though three existing Premiership teams co-habit with football clubs.

London Welsh argued the primacy of tenure rule breached UK and European competition law and was therefore void and unenforceable. The independent panel, which was comprised of QCs James Dingemans, Ian Mill and Tim Ward, agreed.

"We upheld London Welsh's complaint and concluded that the Primacy of Tenure rule gave rise to an unjustified distortion of competition, contrary to UK and EU competition law," the panel said in a statement.

"While the rule included exemptions for three particular Premiership clubs ('the three club exemption'), there was insufficient justification for the narrowness of that exemption and its restrictive effect on aspirant Championship clubs.

"London Welsh argued and the RFU accepted that the consequence of such a finding was that the provisions that contain the Primacy of Tenure rule in the MSC (minimum standards criteria) are void."

This is the second time the Premiership's minimum standards criteria have failed to stand up to a challenge. Rotherham complained to the Office of Fair Trading after their promotion was blocked in 2002, leading to a change in the definition of primacy of tenure.

Source: http://www.standard.co.uk/pasportsfeeds/london-welsh-on-the-up-after-appeal-7899845.html

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Friday, June 29, 2012

Video: Nike Falls After Big Earnings Miss

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Source: http://video.msnbc.msn.com/cnbc/48013599/

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Simple Minds, Devo, The Church - A Day On the Green

They defined a generation, are revered by critics and adored by fans. In an epic career spanning 30 years and more than 40 million albums sold, Simple Minds travelled from the streets of Glasgow to become one of the world?s biggest bands with a musical majesty that still inspires awe.

Devo?s pioneering sound, style and philosophy had a profound effect on the new wave movement. Influential, subversive and downright entertaining, Devo?s cult status quickly spread to the mainstream and after 30 years, they are finally returning to NZ.

In what promises to be one of the most captivating concerts of the year, Simple Minds and Devo will perform a one-off show in New Zealand for a day on the green in the stunning surrounds of Villa Maria Estate.

Joining them, and adding another highlight to savour, will be one of Australia?s finest, the church. Simple Minds, Devo and the church all in one night ? now that?s what we call a concert not to be missed!

This is the first announcement for the upcoming a day on the green season and marks the fifth year of the acclaimed winery series in New Zealand. With more than 30 concerts presented at five wineries across the country, the event is now well and truly established as a huge part of the summer concert calendar.

And what a show to kick off the season!

Australia was the first place in the world to embrace Simple Minds? music giving the band their first hit single ?Love Song? and first Gold album ?New Gold Dream (81-82-83-84)?. It began a lengthy love affair with Australasia fuelled by a stellar array of hits like ?Don?t You (Forget About Me)?, ?Alive and Kicking?, ?Love Song?, ?Promised You A Miracle?, ?Glittering Prize? and ?Waterfront?.

In the live concert arena, Simple Minds have few peers. This is a band that has played countless sold out stadium tours including three times at Wembley stadium, has been voted the prestigious Q Magazine?s ?World?s Best Live Act? and has retained a an enviable reputation as one of the great live concert bands.

Simple Minds commence a lengthy European tour in late June in support of their just released box set ?Simple MindsX5? which features their ground-breaking first five albums ?Life in a Day?, ?Real to Real Cacophony?, ?Empires and Dance?, ?Sons and Fascination/Sister Feelings Call? and ?New Gold Dream (81?82?83?84)? as well as a bonus disc of rare and previously unavailable B-sides and remixes.

According to the UK Guardian Newspaper ?Simple Minds are suddenly alive and kicking again? whilst the Metro says: ?It?s official, Simple Minds are cool again.?

There?s no denying the influence Devo ? brothers Mark and Bob Mothersbaugh and Gerald and Bob Casale - have exercised over a new generation of artists.

Devo was an extension of a multi-media exploration of the concept that mankind's progress had ceased, and the process of de-evolution had begun. Their early work from the visionary debut ?Q: Are We Not Men? A: We Are Devo? caught the attention of such icons as Brian Eno and David Bowie, and with hits like ?Whip It? and ?Girl U Want? and the accompanying revolutionary music videos, the group became one of the defining acts of the 1980s.

Devo?s surrealist and highly innovative stage shows have been an influence on artists from Rage Against the Machine to Lady Gaga. Kurt Cobain once said, "Of all the bands who came from the underground and actually made it in the mainstream, Devo is the most challenging and subversive of all."

In 2010 Devo released their first album in 20 years ?Something For Everyone? and have re-ignited their passion for live performance. They are about to tour the US with Blondie so will be in fine form when they hit our shores for the first time since 1982. Devo-tees - expect the unexpected!

Having recently celebrated their 30th anniversary, the church continue to redefine what it is to be a band, evolving without compromise into one of the world?s most acknowledged melodic art-rock groups.

Source: http://www.eventfinder.co.nz/2012/simple-minds-devo-the-church-day-on-the-green/auckland/mangere?utm_medium=rss

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Thursday, June 28, 2012

$367500 :: 6320 Dawn AVE, Lake Oswego OR, 97035 ? Lake ...

5 beds, 3 full baths
Home size: 2,400 sq ft
Lot Size: 10,454 sq ft
Property Type: DETACHD
MLS Number: 12599375

Beautiful Remodel on oversized lot in Bridgeport Village area. New paint, new kitchen, new carpet, new lighting, new bathrooms, hardwoods, spacious deck in a park like setting.

Listed with Stellar Realty Northwest


Brought to you by Chris Larsson, Coldwell Banker Seal. Call me today at 503-683-2897!

The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS? of Portland, Oregon. All real estate listings are marked with the RMLS? logo, and detailed information about these properties includes the names of the listing brokers. Listing content is ? 2009 RMLS?, Portland, Oregon.


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Bad Posture tells you to sit up straight, replaces your mom with an Arduino

Bad Posture tells you to sit up straight, replaces your mom with an Arduino

At certain point in every geek's life, their mother gives up and stops yelling at them to sit up straight. If the lack of constant reminders to maintain good posture has you slouching and hunching, there are countless technological substitutes. Even a few nice DIY ones. But we've got to give Ellen Sundh props for the simplicity of her solution. While similar projects rely on accelerometers, which can be difficult for the budding hobbyist to work with, to monitor the angle of your body, Bad Posture sticks with a simple bend sensor to keep tabs on your spinal cord. The flexible plastic is arranged vertically in a fabric belt that also houses an Arduino, a Wave Shield from Adafruit and a push button for calibration. Sit at your optimal angle, press the button and you're ready to go. Bend too much and the Wave Shield plays a warning -- "bad posture!" Check out the video after the break to see it in action.

Continue reading Bad Posture tells you to sit up straight, replaces your mom with an Arduino

Bad Posture tells you to sit up straight, replaces your mom with an Arduino originally appeared on Engadget on Tue, 26 Jun 2012 14:21:00 EDT. Please see our terms for use of feeds.

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Tuesday, June 26, 2012

Obama offers storm assistance to Florida governor

(AP) ? President Barack Obama has assured Florida Gov. Rick Scott that his state will have "no unmet needs" as it responds to extreme weather and flooding from Tropical Storm Debby.

White House spokesman Jay Carney says Obama expressed his condolences for the loss of life, as well as the extensive storm damage. Carney says Obama told Scott the federal government would be in close contact with the state and stood ready to provide additional assistance if necessary.

Debby has socked Florida with high winds and heavy rain that has already led to flooding, with officials warning of more to come.

Obama called Scott from Air Force One as he flew to Atlanta for a campaign event. The president will be in Miami later Tuesday to attend two campaign fundraisers.

Associated Press

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Monday, June 25, 2012

Tunisia extradites former Gadhafi PM to Libya - World News

By Reuters

TRIPOLI - Tunisia has extradited former Libyan leader Moammar Gadhafi's prime minister to Libya, a Libyan security official said on Sunday, making him the first senior official to be sent back for trial under the country's transitional leadership.?

Defense ministry official Mohammed al-Ahwal told Reuters that a helicopter transferred Al Baghdadi Ali al-Mahmoudi to Tripoli on Sunday.?


"Mahmoudi is now in Tripoli and we are holding him in a prison," Ahwal said.?

Mahmoudi served as the Libyan dictator's prime minister from 2006 until he fled to neighboring Tunisia around the time that rebel fighters took the capital Tripoli in August.?

Libya begins battle to seize $20 billion in Gadhafi assets - starting with London mansion

His extradition could establish a precedent for other countries who have given refuge to or arrested members of Gadhafi's old entourage.?

Tripoli considers it a matter of national pride and a measure of the country's transformation that trials of people like Mahmoudi and Gadhafi's imprisoned son Saif al-Islam be held in Libya.?

But human rights groups question whether its justice system can meet the standards of international law and say he should be handed over to the ICC instead.?

A Tunisian court ruled as far back as November that Mahmoudi should be extradited. But Tunisian President Moncef al-Marzouki later said the handover would not happen until the situation in Libya had stabilized and Mahmoudi could be guaranteed a fair trial after Gadhafi himself was killed by rebels and his rotting corpse left on display.?

More world news from msnbc.com and NBC News:

Follow us on Twitter: @msnbc_world

?

Copyright 2011 Thomson Reuters. Click for restrictions.

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The Anatomy Of A Pass, A Quantitative Analysis On Why A VC Passes

It is an exciting time for early stage technology company building and venture capital. ?Despite some early bumps in Facebook?s recent IPO (my thoughts here), we are seeing something of a return in the IPO market, as Facebook, LinkedIn, Groupon, Zynga, Jive and others have gone out. ?On the company formation side, founder momentum seems to be surging. ?Every week, I learn about about new incubators and startup accelerators getting formed. Applications are surging to top tier incubators Y-Combinator, 500Startups, and TechStars. To be sure, it is an exciting time.

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New Report Spices Market (2011-2016) by MarketsandMarkets ? Albany Times Union

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Sunday, June 24, 2012

Mercedes-Benz Opens Automated Automotive Fuel Cell Production Facility in Canada

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Fuel Cell Today is the leading organisation for market based intelligence on the fuel cell industry. Covering key trends and developments in industry and government, Fuel Cell Today has provided relevant, unbiased and objective information allowing decision makers to take advantage of the opportunities that our new industry offers.

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Long-term testosterone treatment for men results in reduced weight and waist size

ScienceDaily (June 23, 2012) ? In testosterone-deficient men, major weight loss was an added benefit of testosterone replacement therapy for most of the patients who participated in a new study.

The results will be presented June 23 at The Endocrine Society's 94th Annual Meeting in Houston.

"The substantial weight loss found in our study -- an average of 36 pounds -- was a surprise," said the study's lead author, Farid Saad, PhD, of Berlin-headquartered Bayer Pharma.

Although prior studies using testosterone therapy in testosterone-deficient men consistently show changes in body composition, such as increased lean mass and decreased fat mass, Saad said the net effect on weight seemed unchanged in those studies. However, Saad said their study, which took place in Germany, had a longer follow-up by at least two years and used long-acting injections of testosterone.

The investigators restored testosterone to normal levels in 255 testosterone-deficient ("hypogonadal") men, whose average age was nearly 61 (range, 38 to 83 years). Treatment lasted for up to five years, with injections given at day 1, after 6 weeks and then every 12 weeks after that. Patients did not follow a controlled diet or standard exercise program but received advice to improve their lifestyle habits.

On average, the men weighed 236 pounds before beginning testosterone treatment and 200 pounds after treatment (106.2 versus 90 kilograms), the authors reported. Weight loss was reportedly continuous, with an average reduction in body weight ranging from about 4 percent after one year of treatment to more than 13 percent after five years.

In addition, men lost an average of nearly 3.5 inches (8.8 centimeters) around their waist.

"These results are encouraging because studies show that weight loss drugs and lifestyle interventions have been largely unsuccessful, especially long term," Saad said.

Testosterone deficiency becomes more common with age. Saad said many middle-aged men with testosterone deficiency are obese, explaining that there is "a vicious circle" in obesity and low testosterone.

"Obesity is associated with reduced testosterone, and low testosterone induces weight gain," Saad wrote in the study abstract.

Testosterone replacement is the standard treatment for most men with symptomatic testosterone deficiency, according to The Endocrine Society guidelines.

In the study by Saad and colleagues, treatment used a slow-release, injectable form of the male hormone (testosterone undecanoate) that is not yet available in the United States. It is marketed in Europe, Latin America, Australia and parts of Asia and Africa.

Saad is an employee of Bayer Pharma, which makes a brand of testosterone undecanoate and which partially funded the study in its final two years.

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Facebook signs mobile apps privacy agreement

Published: Jun 22, 2012 at 2:10 PM PDT
SAN FRANCISCO (AP) - Facebook became the seventh company to agree to give people advance warning if its mobile applications pull personal information from mobile phones and tablet computers.

California Attorney General Kamala D. Harris said Friday that the agreement includes Facebook's own applications, as well as those made by third parties in its recently-launched App Center.

The agreement requires mobile apps seeking to collect personal information to display their privacy policies before their app is installed on a device.

Facebook says it incorporated the principles of the privacy agreement when it was designing its App Center.

The other six companies are Apple Inc., Google Inc., Amazon.com Inc., Microsoft Corp., Research in Motion Ltd. and Hewlett-Packard Co.

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Germ Culprits in Moldy, Water-Damaged Buildings Identified

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Joe the Plumber Says Comment About 6M Jews Killed Between 1938 and 1945 in Germany Wasn't About the Holocaust (Little green footballs)

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President Obama: We don't need an outsourcing pioneer in the Oval Office (Washington Bureau)

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NVCI: Report: #Smoking tied to one type of #skin #cancer: http://t.co/uW0YUdBE via @Reuters

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Friday, June 22, 2012

Nintendo Announces the New 3DS XL

  This week Nintendo announced the 3DS will no longer be an only child. This summer Nintendo will be releasing the 3DS XL (on the right), a larger version of its sibling. Along with being bigger overall, screen real estate goes up by 90%. The XL’s top screen is 4.9 inches and the bottom screen [...]

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News Summary: First new BlackBerry gets touch only

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Thursday, June 21, 2012

More, Please (Theagitator)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

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Graphene Research: Trapping light in a carbon net

ScienceDaily (June 21, 2012) ? Graphene, an ordered monolayer of carbon, is the thinnest substance known, and yet has extraordinary mechanical strength. A new study shows that its two-dimensional network of atoms can even trap light.

Thin, thinner, graphene. Graphene, a monolayer of carbon in which the atoms are arranged in a two-dimensional honeycomb network, is the thinnest net in the world, is highly stable. Andre Geim and Konstantin Novoselov received the Nobel Prize for Physics in 2010 for their discovery of the electrical conductivity of graphene. Indeed, graphene could in future replace silicon as the basis for extremely small and extremely fast transistors, and is therefore the subject of intense research.

The high mobility of electrons in graphene arises from the fact that they are confined to the hexagonal lattice. An international team led by the American physicist Dimitri Basov has now shown that photons too can be trapped within the lattice and move freely along it. "It is even possible to control the light waves within the lattice," says physicist Dr. Fritz Keilmann, who is affiliated with LMU Munich, the Center for Nanoscience (CeNS) and the Max Planck Institute for Quantum Optics (MPQ), and contributed significantly to the new work.

Computers with optical switches

Such control can be exerted using electric fields and currents. Hence, in future, the behavior of light in graphene could be tuned electrically, and the converse may also be feasible. Since the light is confined to nanocables with dimensions of a millionth of a millimeter, switching times could be reduced to less than a picosecond (0.000000000001 sec). "It might even be possible to develop computers whose graphene transistors could be switched both optically and electrically," says Keilmann.

Theoretical calculations had previously suggested that photons, specifically long-wavelength infrared photons, could indeed be propagated along the graphene lattice at greatly reduced velocities. The slowing effect was attributed to the formation of plasmons, a type of hybrid particle produced by coupling of the photons to electronic excitations in graphene. It has not been possible to study the predicted plasmons experimentally, because the momentum of the infrared photons was far too low to excite them.

Bringing photons to the point

This problem has now been solved with the aid of a tiny metal pin with a nanometer-sized tip. Acting like a lightning rod, it concentrates incident light into a very small volume. This raises the momentum of infrared photons by up to 60-fold, giving them the extra momentum they need to launch plasmonic waves along the graphene layer. For this purpose, the researchers made use of a commercial infrared scanning near-field microscope, whose finely honed scanning tip is normally used to map the chemical composition of a material under test

In this case only the edge zone of a graphene sample was imaged. Reflection of the plasmons at this edge produces an interference pattern, which encodes information that can be used to confirm formation of the plasmons. It also allows one to deduce many of their properties, such as the magnitude of the reflection at the graphene edge and the change in the velocity by external electric bias, which is of particular interest for future applications. "The long-sought ability to control light signals by electrical means has thus been realized," says Keilmann.

An independent study carried out by a Spanish group, based on the use of a graphene sheet formed by deposition from the gas phase rather than the exfoliated film used in the LMU work, comes to a similar conclusion. The two papers have now appeared back-to-back in the top-tier journal Nature, underlining the significance of these findings for the field of nanoelectronics.

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Story Source:

The above story is reprinted from materials provided by Ludwig-Maximilians-Universit?t M?nchen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Z. Fei, A. S. Rodin, G. O. Andreev, W. Bao, A. S. McLeod, M. Wagner, L. M. Zhang, Z. Zhao, M. Thiemens, G. Dominguez, M. M. Fogler, A. H. Castro Neto, C. N. Lau, F. Keilmann, D. N. Basov. Gate-tuning of graphene plasmons revealed by infrared nano-imaging. Nature, 2012; DOI: 10.1038/nature11253

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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Wednesday, June 20, 2012

Danish Parliament on Visit to China



19 June 2012 | news Newsdesk
From June 17-23 the Foreign Policy Committee of the Danish Parliament is visiting China. The members of the Committee will meet with a number of important institutions and organizations in both Beijing and the Western Province Qinghai to discuss China?s environmental, social, economic and political challenges, foreign policy and growing role on the international stage.

On Monday the Foreign Policy Committee among met with Vice Minister Zhu Weiqun of the United Front Work Department, Vice Minister of the International Department of CPC Liu Jieyi, Member of the Ministerial Leadership in the Ministry of Foreign Affairs, Xie Hangsheng and Vice Chairman of Foreign Affairs Committee of the National People's Congress, Ma Wenpu. The Committee also had a meeting with the Vice Chairman of the National People?s Congress, Ismail Tiliwaldi.
?
From Tuesday till Thursday the delegation will be visiting Xining and Yushu in Qinghai Province before heading back to Beijing Friday. The stay in Qinghai will include meetings with provincial Party Secretary Qiang Wei, Qinghai Development and Reform Commission, the Ethnic Affairs Commission, Yushu Tibetan Prefecture People?s Congress and visits to local villages in Yushu.

::top:: ::top::

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ResCap Judge Approves Probe Into Pre-Bankruptcy Deals ...

The judge overseeing Residential
Capital LLC?s bankruptcy ordered a probe of the mortgage
company?s proposal to settle legal claims against its parent
Ally Financial Inc. (ALLY) (ALLY) that may be worth billions of dollars.

U.S. Bankruptcy Judge Martin Glenn today granted a request
from Berkshire Hathaway Inc. (BRK/A) (A), the holding company run by
billionaire Warren Buffett, for an independent investigation of
ResCap?s proposal to accept $750 million from Ally to settle
potential legal liability tied to mortgage-related securities.

?Under the facts and circumstances of this case, the court
concludes appointment of an examiner is required,? Glenn said
at a court hearing in Manhattan.

ResCap, based in New York, filed for bankruptcy May 14 with
an agreement making an affiliate of Fortress Investment Group
LLC (FIG) (FIG)
the lead bidder at an auction for its mortgage lending and
servicing unit. Ally, a Detroit-based bank that specializes in
car loans, is 74 percent-owned by the U.S. Treasury after
receiving a bailout.

Glenn put off deciding some details of the investigation,
including how much money the examiner will have to spend and
when a public report on the probe will be due. Those issues will
be decided after the U.S. Trustee names an examiner, Glenn said.

Ally has agreed to pay $750 million to ResCap, purchase as
much as $1.6 billion of securities if others don?t, and provide
$150 million to help finance ResCap?s operations during
bankruptcy, according to a company statement.

Berkshire owns about $900 million of ResCap?s junior
secured bonds. Berkshire argued that various deals ResCap made
with Ally and others while preparing to file bankruptcy should
be investigated by an independent, court-approved examiner.

Glenn has already approved a similar investigation being
conducted by the official committee of unsecured creditors,
which is typical in large bankruptcy cases.

ResCap?s 6.5 percent, unsecured bonds that mature next year
rose 4.6 percent to 23 cents on the dollar, according to Trace,
the bond-price reporting system of the Financial Industry
Regulatory Authority.

Of ResCap?s 33 biggest unsecured claims, 32 were related to
active or potential mortgage-securities litigation, according to
court papers. ResCap didn?t give a value for the claims and said
it disputes all of them.

Berkshire is also seeking to buy ResCap?s mortgage
servicing unit for about $2.4 billion and a portfolio of loans
for about $1.45 billion, according to court documents.

Before ResCap filed for bankruptcy it agreed to name
Fortress? Nationstar Mortgage Holdings Inc. (NSM) (NSM) as the lead bidder
for the mortgage unit and Ally as the lead bidder for the loan
portfolio.

The case is In re Residential Capital LLC, 12-12020, U.S.
Bankruptcy Court, Southern District of New York (Manhattan).

To contact the reporter on this story:
Steven Church in Wilmington, Delaware, at
schurch3@bloomberg.net

To contact the editor responsible for this story:
John Pickering at
jpickering@bloomberg.net

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Broken Sports: 12 Red Cards and a Tennis Player Assaulting ...

David Nalbandian bloodies a linesman after kicking an advertising board

British police will open an investigation into David Nalbandian for his role in bloodying a linesman while kicking an advertising board during Sunday?s final at Queen?s Club.

Officials ruled that the Argentine had to default the match to Marin Cilic after smashing the sign with his right foot. During that brief outburst, Nalbandian made contact with line judge Andrew McDougal and sent part of the sign flying into his leg. McDougal was bloodied in the encounter but suffered no other injury.

?

12 Red Cards and Lots of Karate Kicks

Votuporanguense beat Fernandopolis 2-1 in a Campeonato Paulista second division (the fourth tier of the Sao Paulo state championship)?match that ended with a brawl and 12 red cards. The unrest began when the winning side?s striker was taken down by Fernandopolis? goalkeeper on a one v one. The keeper was shown the first red, then everyone got angry.

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Tuesday, June 19, 2012

Scientists discover mechanism that promotes lung cancer growth and survival

Monday, June 18, 2012

A multi-institutional research study has uncovered a new mechanism that may lead to unique treatments for lung cancer, one of the leading causes of death worldwide.

The study recently published in the journal Genes & Developmentwas a collaboration between Sanford-Burnham Medical Research Institute, Virginia Commonwealth University (VCU) Massey Cancer Center and the VCU Institute of Molecular Medicine, the University of California, San Diego, the University of Minnesota and St. Jude Children's Research Hospital. The scientists discovered that the protein Bax Inhibitor-1 (BI-1) protects lung cancer cells and promotes tumor growth by regulating autophagy, a complex process initiated under stressful conditions that breaks down a cell's own components to provide nutrients needed for survival.

"Cancer cells are remarkably adaptive and depend on a variety of mechanisms to ensure their survival and continued growth when challenged by their environment," says John C. Reed, M.D., Ph.D., professor and CEO of Sanford-Burnham. "By reducing levels of BI-1, it appears we were able to modulate intracellular signals and starve lung cancer cells of the energy needed to carry out one of their most important survival mechanisms, autophagy."

The researchers showed that BI-1 appeared to be linked to levels of calcium, which aids in signal transduction. Suppressing BI-1 reduced calcium levels in the endoplasmic reticulum, the interconnected network of sacs and tubules that manufacture, process and transport a variety of compounds for use inside and outside of cells. Lowering BI-1 levels led to reduced mitochondrial activity, oxygen consumption and adenosine triphosphate (ATP) levels. ATP is often called the "molecular unit of currency" due to the important role it plays in transporting chemical energy needed for metabolism.

The researchers' laboratory findings were confirmed by animal models that showed BI-1 suppression reduced human lung cancer tumor growth.

"These studies are the first to show that BI-1 may play an important survival role in cells under circumstances where oxygen and nutrient deprivation are encountered, such as the conditions that arise in advanced tumors or when cells are stressed by chemotherapy treatments," says Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair in Cancer Research and program co-leader of Cancer Molecular Genetics at VCU Massey Cancer Center, chairman of VCU's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine. "We are excited by our findings because they uncover a new pathway that may be an effective target for future therapies to treat advanced lung cancer."

Next, the scientists hope to apply their findings to screen for potential drugs that can reduce BI-1-mediated protective autophagy in cancer cells.

###

Virginia Commonwealth University: http://www.vcu.edu

Thanks to Virginia Commonwealth University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Nas Is Like 'An Old Blues Man' On Life Is Good Album Cover

Cover features rapper sitting with ex-wife Kelis' wedding gown draped across his knee.
By Rob Markman


Nas' Life is Good album cover
Photo:

A bright splash of green is all it took to make the album cover for Nas' Life Is Good pop, but coincidentally for God's Son, it's all just a case of the blues.

"The cover is like an old blues man talking about his life," Nas told MTV News about the striking image for his upcoming 10th solo shot.

There's Nasir Jones, sitting pensive, with his hand to his chin, wearing a crisp white, casually unbuttoned suit. On his lap is a green wedding dress, the same green wedding dress that his ex-wife Kelis wore during their 2005 wedding ceremony; the same green dress that she left hanging in his closet after their divorce.

When VH1 profiled the rapper on their "Behind the Music" special, the usually private Nas spoke in detail about his split from the R&B singer. "She took her stuff out of the house and left her green wedding dress. And that was all she left," he said, his voice marked by heartbreak.

It was in that very moment, during the VH1 interview, that Nas knew what he had to do for his next album cover. "It clicked right there. You're saying it even in your interview, it's like a given that this should allude to this being on the cover, that statement," he said. "Some things you can't plan, they happen."

Throughout his career, the gifted lyricist has always delivered strong images, and it's all very deliberate. Before fans even got a complete listen of Nas' 1994 classic debut Illmatic, the album's cover let you know that you were in for something special. The cover image of a prepubescent Nas, with his hardened gaze juxtaposed against his native Queensbridge housing project has become just as indelible as the 10 tracks that it housed.

On his next three album covers, Nas built upon that first Illmatic image. The front panel for his 1996 sophomore disc It Was Written re-created the same look, but with an image of a more grown-up Nas. On I Am, Nasir once again posed against Queensbridge, but this time he appeared as a pharaoh. And on Nastradamus, he used the same backdrop but played the role of a prophet, with a brown hood over his head.

By the time 2001's Stillmatic was released, Nas had abandoned the Queensbridge concept and created an image faintly reminiscent of Slick Rick's 1988 debut, The Great Adventures of Slick Rick. With 2004's Street's Disciple cover, Esco re-created a Last Supper theme, and on his controversial 2008 Untitled album, a shirtless Nas appeared as a slave, with welts on his back that formed the letter 'N.'

When the already-iconic MC looks back at his career, he wants to be remembered for his cover art. He takes his cues from memorable LPs like Earth Wind & Fire's Last Days and Time and Iron Maiden's self-titled 1980 debut. "I wanna be the one, like Earth Wind & Fire and Iron Maiden, like album covers that just really stand out," he said. "I want to be the guy with the best album cover story."

Life Is Good is due out July 17.

What's your favorite Nas album cover? Let us know in the comments!

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Calif. man rescued after whale knocks hole in boat

A Northern California man was rescued after his 50-foot boat was struck by a whale while he sailed alone about 40 miles off the western coast of Mexico, authorities said.

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The impact from the collision knocked out the sailboat's steering and the vessel began taking on water late Tuesday, U.S. Coast Guard Petty Officer 2nd Class Pamela Boehland said.

Max Young of Sacramento stuffed a mattress into the hole caused by the whale, turned on four bilge pumps and was "trying to bail out water as fast as he could, because he didn't know how long it would take to be rescued," his wife, Debra Young, told The Associated Press.

He also activated an emergency beacon, which alerted the Coast Guard.

"His EPIRB delivered an exact position to us, contact information that allowed us to quickly discern the sail plan of and number of persons on the vessel, and really took a lot of the search out of the search and rescue," said Lt. Charles Kelly, of the Coast Guard's command center in Alameda, Calif.

With that information, officials at the command center were able to immediately direct a merchant ship, which was about 60 miles away, to the sinking craft.

Meanwhile, as the rescue efforts were just beginning, Young was initially unaware that the boat was taking on water, his wife said.

"He was steering the boat and trying to get it back on course," Debra Young said. "It took him a while to realize he didn't have any steerage at all. It took him a bit longer to realize he was taking on water."

When the freighter arrived at around 4 a.m. Wednesday, Young scrambled off his boat by a rope ladder thrown by the ship's crew.

Young had been on the final leg of a trip from the East Coast to a marina in Emeryville, Calif., when the collision took place. The 67-year-old has been sailing for at least 30 years, but having worked on boats with his father, who was a commercial fisherman, he's been on the ocean most of his life, his wife said.

Debra Young said she has been able to talk to her husband while he's on board the merchant ship. He's not expected to make it back to Sacramento for another week or so.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Monday, June 18, 2012

Switched On: Going Thermonuclear

Each week Ross Rubin contributes Switched On, a column about consumer technology.

DNP Switched On Going Thermonuclear

At the debut of the T-Mobile G1, Switched On identified the central conflict that would quickly tear apart the goodwill between Apple and Google. In fact, in Steve Jobs' authorized biography, Walter Isaacson quotes the late Apple CEO on Android, noting that the he was prepared to "go thermonuclear war" on the iOS competitor. Indeed, the first WWDC since Jobs' death was filled with enough anti-Google swipes to smudge every iPhone screen in Moscone West. But the verbal lashings were nothing compared to the beating back that Google and Android took in relation to iOS 6 feature announcements.

Continue reading Switched On: Going Thermonuclear

Switched On: Going Thermonuclear originally appeared on Engadget on Sun, 17 Jun 2012 18:03:00 EDT. Please see our terms for use of feeds.

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